Produção Nacional
Revisado por pares
Common bean protein hydrolysate modulates lipid metabolism and prevents endothelial dysfunction in BALB/c mice fed an atherogenic diet
2019; Elsevier BV; Volume: 30; Issue: 1 Linguagem: Inglês
10.1016/j.numecd.2019.07.020
ISSN1590-3729
AutoresMariana Juste Contin Gomes, Sâmara Letícia Silva de Lima, Natália Elizabeth Galdino Alves, Andressa de Assis, Maria Eliza de Castro Moreira, Renata Celi Lopes Toledo, C.O. Barbosa Rosa, Olivia Reis Teixeira, P. Z. Bassinello, Elvira González de Mejı́a, Hércia Stampini Duarte Martino,
Tópico(s)Phytoestrogen effects and research
ResumoBackground and aimsCommon beans (Phaseolus vulgaris L.) protein hydrolysate is a source of bioactive peptides with known health benefits. The aim of this study was to evaluate the effect of common bean protein hydrolysate on lipid metabolism and endothelial function in male adult BALB/c mice fed an atherogenic diet for nine weeks.Methods and resultsMale adult mice were divided into three experimental groups (n = 12) and fed with normal control diet; atherogenic diet and atherogenic diet added with bean protein hydrolysate (700 mg/kg/day) for nine weeks. Food intake, weight gain, lipid profile, Atherogenic Index of Plasma, inflammation biomarkers and endothelial function were evaluated. APH group presented reduced feed intake, weight gain, lipid profile, tumor necrosis factor-α, angiotensin II (94% and 79%, respectively) and increased endothelial nitric oxide synthase (62%).ConclusionsProtein hydrolysate showed hypocholesterolemic activity preventing inflammation and dysfunction of vascular endothelium, in addition to decreasing oxidative stress, indicating an adjuvant effect on reducing atherogenic risk.
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