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Cytokines and chemokines triggered by Chikungunya virus infection in human patients during the very early acute phase

2019; Oxford University Press; Volume: 113; Issue: 11 Linguagem: Inglês

10.1093/trstmh/trz065

1878-3503

Ithallo Sathio Bessoni Tanabe, Elane Conceição dos Santos, Eloiza Lopes Lira Tanabe, Stephannie Janaina Maia de Souza, Fabio E F Santos, Jamile Taniele-Silva, Jean F G Ferro, Magliones Carneiro de Lima, Adriana Ávila Moura, Letícia Anderson, Ênio José Bassi,

Malaria Research and Control

The immune response against the Chikungunya virus (CHIKV) during the very early acute phase is not fully elucidated. Therefore we explored the cytokine and chemokine profile triggered by CHIKV in infected patients.Cytokines, chemokines and C5a anaphylatoxin were analysed in serum from CHIKV-infected patients during the viraemic phase (mean 2.97±1.27 d after illness onset) compared with a healthy group.CHIKV-infected patients had a significant increase of interferon-α (IFN-α), interleukin-6 (IL-6), interleukin-8 (CXCL8/IL-8), interleukin-10 (IL-10), interferon-γ (IFN-γ), monokine induced by interferon-γ (CXCL9/MIG), monocyte chemoattractant protein-1 (CCL2/MCP-1), interferon-γ-induced protein-10 (CXCL10/IP-10) and complement C5a anaphylatoxin.The very early acute immune response triggered against CHIKV leads to an increase in pro-inflammatory immune mediators such as IFN-γ and its induced chemokines, and a high level of C5a anaphylatoxin as a result of complement activation.