Early Airway Pathological Changes in Children: New Insights into the Natural History of Wheezing
2019; Multidisciplinary Digital Publishing Institute; Volume: 8; Issue: 8 Linguagem: Inglês
10.3390/jcm8081180
ISSN2077-0383
AutoresMatteo Bonato, Mariaenrica Tinè, Erica Bazzan, Davide Biondini, Marina Saetta, Simonetta Baraldo,
Tópico(s)Neonatal Respiratory Health Research
ResumoAsthma is a heterogeneous condition characterized by reversible airflow limitation, with different phenotypes and clinical expressions. Although it is known that asthma is influenced by age, gender, genetic background, and environmental exposure, the natural history of the disease is still incompletely understood. Our current knowledge of the factors determining the evolution from wheezing in early childhood to persistent asthma later in life originates mainly from epidemiological studies. The underlying pathophysiological mechanisms are still poorly understood. The aim of this review is to converge epidemiological and pathological evidence early in the natural history of asthma to gain insight into the mechanisms of disease and their clinical expression.
Referência(s)