Portal de Periódicos da CAPES

Successful use of topical minoxidil in the treatment of hypotrichosis associated with desmoplakin mutations

2019; Wiley; Volume: 36; Issue: 6 Linguagem: Inglês

10.1111/pde.13966

1525-1470

Margaret Dowd, Nina K. Antonov, Maria C. Garzón, Christine T. Lauren,

Ginseng Biological Effects and Applications

Abstract Syndromes associated with desmosomal protein mutations such as desmoplakin can result in hair abnormalities including congenital alopecia and hypotrichosis. Herein, we present an 8‐year‐old boy, with a combination of two heterozygous mutations in the DSP gene encoding desmoplakin associated with congenital alopecia and long‐standing hypotrichosis, who was treated with off‐label use of topical minoxidil 5% foam once daily with dramatic growth after 2 months of therapy and sustained results at 1 year. Topical minoxidil may be effective in management of congenital alopecia and hypotrichosis associated with desmoplakin mutations.