Produção Nacional
Revisado por pares
Toxicological properties of an aqueous extract of Aristolochia triangularis leaves, using the brine shrimp lethality and Allium cepa bioassays
2019; UNIVERSIDADE FEDERAL DE SANTA MARIA; Volume: 49; Issue: 8 Linguagem: Inglês
10.1590/0103-8478cr20190091
ISSN1678-4596
AutoresJosé Darlan Alves da Silva, Cláudio Rodrigo Nogueira, Maria do Carmo Vieira, Silvia Cristina Heredia Vieira, Alexéia Barufatti, Bruno do Amaral Crispim, Luiza Flávia Veiga Francisco, Lucilene Finoto Viana, Claúdia Andréa Lima Cardoso,
Tópico(s)Heavy Metals in Plants
ResumoABSTRACT: The aqueous extract of Aristolochia triangularis leaves showed activity against Artemia salina larvae, with an LD50 of 370.6 µg/mL. In experiments with Allium cepa seeds, the extract caused a 51.26% reduction in the germination index, inhibited mean root growth, and was cytotoxic at concentrations of 668 and 2,000 µg/mL. Its antioxidant activity was additionally assessed in this research and the ferric reducing antioxidant power value was found to be 391.2 µM/g. Such health-beneficial property can be attributed partly to the total phenolic content, spectrophotometrically determined as 52.67 mg/g. The occurrence of cytotoxicity suggested caution when consuming teas from A. triangularis leaves for medicinal purposes, and equally reveals the need for further studies to investigate their adverse effects.
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