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Effect of exercise on epicardial fat in adults: a protocol for systematic review and meta-analyses

2019; Volume: 5; Issue: 1 Linguagem: Inglês

10.15761/jic.1000272

ISSN

2058-3702

Autores

Leonardo Roever, Elmiro Santos Resende, Angélica Lemos Debs Diniz, Nilson Penha‐Silva, João Lucas O’Connell, Fernanda Rodrigues de Souza, Poliana Rodrigues Alves Duarte, Leandro Teixeira Paranhos Lopes, Paulo Fernando Silva Gomes, Hugo Ribeiro Zanetti, Anaisa Silva Roerver-Borges, Fernando César Veloso, Thiago Montes Fidale, Antonio Casella–Filho, Paulo Magno Martins Dourado, Antônio Carlos Palandri Chagas, Sadeq Ali‐Hasan‐Al‐Saegh, Paulo Eduardo Ocke Reis, Rogério de MeloCosta Pinto, Gustavo B.F. Oliveira, Álvaro Avezum Mansueto Neto, André Rodrigues Durães, Rose Mary Ferreira Lisboa da Silva, Antônio José Grande, Celise Denardi, Renato D. Lópes, Nitesh Nerlekar, Shahab Alizadeh, Adrían V. Hernández, Maria Inês da Rosa, Gary Tse, Tong Liu, Roberto Furlanetto Júnior, Camilo Luís Monteiro Lourenço, Giuseppe Biondi‐Zoccai,

Tópico(s)

Cardiovascular Effects of Exercise

Resumo

Introduction: Epicardial adipose tissue (EAT) is a complex disease that includes endothelial dysfunction, insulin resistance, diabetes, hypertension, ectopic obesity, and dyslipidaemia and an increased risk of cardiovascular events.This study aims to fill this gap of research by conducting a systematic review and meta-analysis to compare differences types of exercise to reduce EAT. Methods and analysis:We will search the PubMed, EMBASE, Cochrane Library, Web of Science, Embase, google scholar, clinical trials registry (ClinicalTrials.gov) for unpublished or undergoing research listed in registry platforms.Randomized controlled trials (RCTs) on the drug therapy of EAT with outcome measures including diagnostic criteria of EAT will be included.The quality of included RTCs will be evaluated according to the Cochrane Collaboration's risk of bias tool.Sensitivity analysis on the sample size of RCTs, meta-regression analysis on the follow-up periods, dosages and baselines of outcome measure, contradiction analysis between pairwise and network meta-analyses, and publication bias analysis, will be performed.The quality of included RTCs will be evaluated according to the Cochrane Collaboration's risk of bias tool.Sensitivity analysis on the sample size of RCTs, meta-regression analysis on the follow-up periods, dosages and baselines of outcome measure, contradiction analysis between pairwise and network meta-analyses, and publication bias analysis, will be performed.

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