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Artigo Acesso aberto Produção Nacional Revisado por pares
BIBTEX RIS

Risk of Zika microcephaly correlates with features of maternal antibodies

2019; Rockefeller University Press; Volume: 216; Issue: 10 Linguagem: Inglês

10.1084/jem.20191061

ISSN

1540-9538

Autores

Davide F. Robbiani, Priscilla C. Olsen, Federico Costa, Qiao Wang, Thiago Y. Oliveira, Nívison Nery, Adeolu Aromolaran, Mateus Santana do Rosário, Gielson Almeida do Sacramento, Jaqueline S. Cruz, Ricardo Khouri, Elsio A. Wunder, Adriana Mattos, Bruno de Paula Freitas, Manoel Sarno, Gracinda Archanjo, Dina Daltro, Gustavo Balthazar da Silveira Carvalho, Kleber Pimentel, Isadora Cristina de Siqueira, João Ricardo Maltez de Almeida, Daniele Freitas Henriques, Juliana Abreu Lima, Pedro Fernando da Costa Vasconcelos, Dennis Schaefer-Babajew, Stephanie A. Azzopardi, Leonia Bozzacco, Anna Gazumyan, Rubens Belfort, Ana P. Alcântara, Gustavo Balthazar da Silveira Carvalho, Lícia Maria Oliveira Moreira, Katiaci Janice Chaves Araujo, Mitermayer Galvão dos Reis, Rebekah I. Keesler, Lark L. Coffey, Jennifer Tisoncik-Go, Michael Gale, Lakshmi Rajagopal, Kristina M. Adams Waldorf, Dawn M. Dudley, Heather A. Simmons, Andrés Mejía, David H. O’Connor, Rosemary J. Steinbach, Nicole N. Haese, Jessica L. Smith, Anne D. Lewis, Lois M. A. Colgin, Victoria H. J. Roberts, Antonio E. Frias, Meredith A. Kelleher, Alec J. Hirsch, Daniel N. Streblow, Charles M. Rice, Margaret R. MacDonald, Antonio R.P. de Almeida, Koen K. A. Van Rompay, Albert I. Ko, Michel C. Nussenzweig,

Tópico(s)

Virology and Viral Diseases

Resumo

Zika virus (ZIKV) infection during pregnancy causes congenital abnormalities, including microcephaly. However, rates vary widely, and the contributing risk factors remain unclear. We examined the serum antibody response to ZIKV and other flaviviruses in Brazilian women giving birth during the 2015–2016 outbreak. Infected pregnancies with intermediate or higher ZIKV antibody enhancement titers were at increased risk to give birth to microcephalic infants compared with those with lower titers (P < 0.0001). Similarly, analysis of ZIKV-infected pregnant macaques revealed that fetal brain damage was more frequent in mothers with higher enhancement titers. Thus, features of the maternal antibodies are associated with and may contribute to the genesis of ZIKV-associated microcephaly.

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