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<p>Gentamicin susceptibility of <em>Neisseria gonorrhoeae</em> isolates from 7 provinces in China</p>

2019; Dove Medical Press; Volume: Volume 12; Linguagem: Inglês

10.2147/idr.s214059

1178-6973

Jingwei Liu, Wenqi Xu, Xiaoyu Zhu, Xiu-Qin Dai, Shao-Chun Chen, Yan Han, Jun Liu, Xiang‐Sheng Chen, Yue-Ping Yin,

Bacterial Infections and Vaccines

Gentamicin is a promising antimicrobial for the treatment of gonorrhea. The study aimed to evaluate gentamicin minimum inhibitory concentrations (MICs) of Neisseria gonorrhoeae isolates in China.In this study, the agar dilution method was used to determine the MICs of 470 isolates collected in 2016 to four effective antimicrobials (gentamicin, azithromycin, ceftriaxone, and spectinomycin).Gentamicin MICs ranged from 1 to 8 mg/L. No isolate was resistant to gentamicin. Of seven isolates simultaneously resistant to azithromycin and ceftriaxone, 6 isolates demonstrated MICs of 4 mg/L or less to gentamicin. No cross relationships were found between MICs of gentamicinand susceptibility profiles of azithromycin, ceftriaxone, and spectinomycin.The in vitro results suggest that gentamicin can be a promising treatment option for gonococcal infections in China. Clinical trials to evaluate the therapeutic efficacy of gentamicin are required.