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BIBTEX RIS

Cashew gum, a biopolymer, topically protects oesophageal mucosa in non erosive reflux disease: A promising translational study

2019; Elsevier BV; Volume: 226; Linguagem: Inglês

10.1016/j.carbpol.2019.115205

1879-1344

Lucas Antônio Duarte Nicolau, Francisco José Batista‐Lima, Ana Paula M. Santana, Thiago M. Sales, João P. Carmo‐Neto, Gutierres B. Freitas, Taiane Maria de Oliveira, Jand Venes Rolim Medeiros, Durcilene Alves da Silva, Chung Lee, Philip Woodland, Pedro Marcos Gomes Soares, Mariana Lima Vale, Armênio Aguiar dos Santos, Daniel Sifrim, Marcellus Henrique Loiola Ponte de Souza,

Esophageal and GI Pathology

This study aimed to investigate a standardized biopolymer, cashew gum (CG), in human oesophageal mucosa and mice with experimentally-induced non-erosive reflux disease (NERD). Human oesophageal biopsies from NERD patients were collected to evaluate the mucosal protection of CG through transepithelial electrical resistance (TER), mucosal permeability, and mucoadhesiveness tests. A surgical model of NERD in mice was induced, and barrier functions followed by suggestive oesophageal inflammatory hallmarks were evaluated. Pre-coating of CG was effective in human oesophageal mucosa by attenuating drop of TER and mucosal permeability. Labelled-CG adheres to human oesophageal mucosa for up to 1 h. In animal studies, CG improved parameters of barrier function (TER and mucosal permeability) in distal oesophagus mucosa. CG also promoted sequential support by reducing inflammatory hallmarks of oesophageal damage. CG confers topical oesophageal mucosal protection due to its mucoadhesiveness and anti-inflammatory profile. Long-duration mucoprotective products can be further explored as first-line/adjuvant NERD therapy.