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An overlapping pattern of cerebral cortical thinning is associated with both positive symptoms and aggression in schizophrenia via the ENIGMA consortium

2019; Cambridge University Press; Volume: 50; Issue: 12 Linguagem: Inglês

10.1017/s0033291719002149

1469-8978

Ting Yat Wong, Joaquim Raduà, Edith Pomarol‐Clotet, Raymond Salvador, Anton Albajes‐Eizagirre, Aleix Solanes, Erick J. Canales‐Rodríguez, Amalia Guerrero‐Pedraza, Salvador Sarró, Tilo Kircher, Igor Nenadić, Axel Krug, Dominik Grotegerd, Udo Dannlowski, Stefan Borgwardt, Anita Riecher‐Rössler, André Schmidt, Christina Andreou, Christian G. Huber, Jessica A. Turner, Vince D. Calhoun, Wenhao Jiang, Sarah Clark, Esther Walton, Gianfranco Spalletta, Nerisa Banaj, Fabrizio Piras, Valentina Ciullo, Daniela Vecchio, Irina Lebedeva, Alexander S. Tomyshev, В. Г. Каледа, Tatyana P Klushnik, Geraldo F. Busatto, Marcus V. Zanetti, Maurício H. Serpa, Pedro G. P. Rosa, Ryota Hashimoto, Masaki Fukunaga, Anja Richter, Bernd Krämer, Oliver Gruber, Aristotle N. Voineskos, Erin W. Dickie, David Tomeček, Antonín Škoch, Filip Španiel, Cyril Höschl, Alessandro Bertolino, Aurora Bonvino, Annabella Di Giorgio, Laurena Holleran, Simone Ciufolini, Tiago Reis Marques, Paola Dazzan, Robin M. Murray, Jelle Lamsma, Wiepke Cahn, Neeltje E.M. van Haren, Ana M. Díaz‐Zuluaga, Julian A. Pineda‐Zapata, Cristian Vargas, Carlos López‐Jaramillo, Theo G.M. van Erp, Ruben C. Gur, Thomas Nickl‐Jockschat,

Advanced Neuroimaging Techniques and Applications

Abstract Background Positive symptoms are a useful predictor of aggression in schizophrenia. Although a similar pattern of abnormal brain structures related to both positive symptoms and aggression has been reported, this observation has not yet been confirmed in a single sample. Method To study the association between positive symptoms and aggression in schizophrenia on a neurobiological level, a prospective meta-analytic approach was employed to analyze harmonized structural neuroimaging data from 10 research centers worldwide. We analyzed brain MRI scans from 902 individuals with a primary diagnosis of schizophrenia and 952 healthy controls. Results The result identified a widespread cortical thickness reduction in schizophrenia compared to their controls. Two separate meta-regression analyses revealed that a common pattern of reduced cortical gray matter thickness within the left lateral temporal lobe and right midcingulate cortex was significantly associated with both positive symptoms and aggression. Conclusion These findings suggested that positive symptoms such as formal thought disorder and auditory misperception, combined with cognitive impairments reflecting difficulties in deploying an adaptive control toward perceived threats, could escalate the likelihood of aggression in schizophrenia.