Produção Nacional
Revisado por pares
Plant Extracts Loaded in Nanostructured Drug Delivery Systems for Treating Parasitic and Antimicrobial Diseases
2019; Bentham Science Publishers; Volume: 25; Issue: 14 Linguagem: Inglês
10.2174/1381612825666190628153755
ISSN1873-4286
AutoresBrenna Louise Cavalcanti Gondim, João Augusto Oshiro, Felipe H.A. Fernanandes, Fernanda Pontes Nóbrega, Lúcio Roberto Cançado Castellano, Ana Cláudia Dantas de Medeiros,
Tópico(s)Nanoparticles: synthesis and applications
ResumoPlant extracts loaded in nanostructured drug delivery systems (NDDSs) have been reported as an alternative to current therapies for treating parasitic and antimicrobial diseases. Among their advantages, plant extracts in NDSSs increase the stability of the drugs against environmental factors by promoting protection against oxygen, humidity, and light, among other factors; improve the solubility of hydrophobic compounds; enhance the low absorption of the active components of the extracts (i.e., biopharmaceutical classification II), which results in greater bioavailability; and control the release rate of the substances, which is fundamental to improving the therapeutic effectiveness. In this review, we present the most recent data on NDDSs using plant extracts and report results obtained from studies related to in vitro and in vivo biological activities.
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