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Major subpopulations of Plasmodium falciparum in sub-Saharan Africa

2019; American Association for the Advancement of Science; Volume: 365; Issue: 6455 Linguagem: Inglês

10.1126/science.aav5427

1095-9203

Alfred Amambua‐Ngwa, Lucas Amenga–Etego, Edwin Kamau, Roberto Amato, Anita Ghansah, Lemu Golassa, Milijaona Randrianarivelojosia, Deus S. Ishengoma, Tobias O. Apinjoh, Oumou Maïga‐Ascofaré, Ben Andagalu, William Yavo, Marielle Karine Bouyou-Akotet, Kolapo Oyebola, Karim Mané, Archibald Worwui, David Jeffries, Victoria J. Simpson, Umberto D’Alessandro, Dominic Kwiatkowski, Abdoulaye Djimdé,

Parasites and Host Interactions

Ebb and flow of parasite populations The population genetics of the malaria parasite Plasmodium falciparum across Africa is poorly understood but important to know for grasping the risks and dynamics of the spread of drug resistance. Harnessing the power of genomics, Amambua-Ngwa et al. of the Plasmodium Diversity Network Africa found substantial population structure within Africa that is consistent with human and vector population divergence (see the Perspective by Sibley). Specific signatures of selection by antimalarial drugs were detected, along with indications of the effect of colonization and slavery. Furthermore, whole-genome sequencing showed that there is extensive gene flow among the different regions and that Ethiopia has a distinctive population of P. falciparum , which may be indicative of coexistence with another malaria parasite, P. vivax. Science , this issue p. 813 ; see also p. 752