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Negative association between serum adropin and hypertensive disorders complicating pregnancy

2019; Informa; Volume: 38; Issue: 4 Linguagem: Inglês

10.1080/10641955.2019.1657887

1525-6065

Dong‐Tsamn Lin, Jian Yong, Shuhua Ni, Weichao Ou, Xuerui Tan,

Adipose Tissue and Metabolism

Objective: Study the association of adropin and hypertensive disorders complicating pregnancy (HDCP).Methods: Patients with HDCP were matched with normotensive women (47 pairs). Adropin concentrations were detected by enzyme-linked immunosorbent assay.Results: Compared with the controls, the serum adropin levels were lower in the HDCP group (P < 0.001) and in HDCP subgroups (gestational hypertension, mild preeclampisa, and severe preeclampsia, term, preterm, early onset, and late onset) (all P < 0.05). After adjustment for confounders, adropin remained negatively associated with HDCP (P = 0.027).Conclusion: Lower adropin concentration is significantly associated with HDCP, suggesting that higher or normal adropin levels may be protective against HDCP.