Efficient access to β- and γ-carbolines from a common starting material by sequential site-selective Pd-catalyzed C–C, C–N coupling reactions
2019; Elsevier BV; Volume: 75; Issue: 40 Linguagem: Inglês
10.1016/j.tet.2019.130569
ISSN1464-5416
AutoresTran Quang Hung, Đỗ Trung Hiếu, Dinh Van Tinh, Ha Nam, Tuan Anh Nguyen Tien, Dang Van Do, Lê Thanh Sơn, Ngọc Hân Trần, Nguyen Van Tuyen, Vu Minh Tan, Peter Ehlers, Tuan Thanh Dang, Peter Langer,
Tópico(s)Synthesis of Indole Derivatives
ResumoAbstract Two efficient and practical approaches are reported for the synthesis of β- and γ-carboline derivatives from 3,4-dibromopyridine as a common starting material. The β-carbolines were prepared by site-selective Pd-catalyzed C–C coupling with o-bromophenylboronic acid and subsequent cyclization by double C–N coupling with amines. γ-Carbolines were prepared from the same starting material by C–N coupling with anilines and subsequent annulation by domino C–C/C–N coupling with o-bromophenylboronic acid.
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