Factors associated with acute exacerbations of myasthenia gravis
2019; Wiley; Volume: 60; Issue: 6 Linguagem: Inglês
10.1002/mus.26689
ISSN1097-4598
AutoresRohit Gummi, Natalie Kukulka, Chelsea B. Deroche, Raghav Govindarajan,
Tópico(s)Antifungal resistance and susceptibility
ResumoThe etiology of acute exacerbations of myasthenia gravis (MG) is not well understood and further characterization can lead to improved preventative measures. This study aims to characterize factors contributing to MG exacerbations.A total of 127 MG patient charts were reviewed retrospectively (2011-2016) to obtain demographics, immunizations, pharmaceutical records, contributing factors of each MG exacerbation, emergency department (ED) visits, hospitalizations, and duration.There were 212 exacerbations requiring 106 ED visits and 141 hospitalizations (average admission 6.5 days). Highest contributors were infections (30%) and medications that may worsen MG (19%), with 24% unattributed. Infection related exacerbations were associated with 44.3% of ED visits and 39.7% of hospitalizations. Patients prescribed beta-blockers were associated with more exacerbations (P < .01). Patients prescribed medications that may worsen MG had a higher exacerbation frequency shortly after administration.Infections and cautioned medications are frequently factors in acute MG exacerbations needing urgent medical attention and warrant caution.
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