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High-fat diet induces mouse liver steatosis with a concomitant decline in energy metabolism: attenuation by eicosapentaenoic acid (EPA) or hydroxytyrosol (HT) supplementation and the additive effects upon EPA and HT co-administration

2019; Royal Society of Chemistry; Volume: 10; Issue: 9 Linguagem: Inglês

10.1039/c9fo01373c

2042-650X

Francisca Echeverría, Rodrigo Valenzuela, Andrés Bustamante, Daniela Álvarez, Macarena Ortíz, Alejandra Espinosa, Paola Illesca, Daniel Gonzalez‐Mañán, Luis A. Videla,

Adipose Tissue and Metabolism

High-fat-diet (HFD) feeding is associated with liver oxidative stress (OS), n-3 long-chain polyunsaturated fatty acid (n-3 LCPUFA) depletion, hepatic steatosis and mitochondrial dysfunction. Our hypothesis is that the HFD-induced liver injury can be attenuated by the combined supplementation of n-3 LCPUFA eicosapentaenoic acid (EPA) and the antioxidant hydroxytyrosol (HT). The C57BL/6J mice were administered an HFD (60% fat, 20% protein, 20% carbohydrates) or control diet (CD; 10% fat, 20% protein, 70% carbohydrates), with or without EPA (50 mg kg