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BIBTEX RIS

Incidence and mortality of myeloid malignancies in children, adolescents and Young adults in Brazil: A population-based study

2019; Elsevier BV; Volume: 62; Linguagem: Inglês

10.1016/j.canep.2019.101583

1877-783X

Suellen Valadares Moura Feliciano, Marceli de Oliveira Santos, Maria S. Pombo‐de‐Oliveira, Josefa Ângela Pontes de Aquino, Terezinha Almeida de Aquino, Miren Maite Uribe Arregi, Berenice Navarro Antoniazzif, Allini Mafra da Costa, Lucrécia Aline Cabral Formigosa, C. Laporte, Carlos Anselmo Lima, Nayara Cabral Machado, Jose C Oliveira, Larissa Dell’Antonio Pereira, Adriana de Souza, Cristina Maria Almeida dos Santos, Paulo César Fernandes de Souza, Donaldo Botelho Venezian,

Lymphoma Diagnosis and Treatment

Myeloid malignancies (MM) are heterogeneous when it comes to incidence rates and pathogenesis. These variation rates are important to generate hypotheses on causal aetiology. This study aimed to describe incidence and mortality patterns of MM among children, adolescents and young adults (cAYA) in Brazil and to evaluate trends in incidence and mortality rate overtime.Data were extracted from a dataset of 15 Population-based Cancer Registries located in five Brazilian geographical regions and calculated by age-specific, crude, and age-standardized incidence (ASR) and mortality rates per million persons. Joinpoint regression analyses were performed for trends evaluations, regionally. Annual Percent Change (APC) and Average Annual Percent Change (AAPC) were also estimated.The overall ASR for incidence and mortality of MM in Brazil was 14.57 and 8.83 per million, respectively. The AML (non-APL AML and APL) incidence rate is 8.18 per million, whereas other MM subtypes altogether have an incidence rate of 2.62 per million, and not otherwise specified (NOS) is 3.70 per million. The analysis of incidence trends (AAPC) showed a significant decline in Manaus (-5.6%) and São Paulo (-4.7%), and a significant increase was observed in Fortaleza (5.8%). Mortality trends steadily declined in all registries, with significant declines occurring in Goiânia (-1.5%), Belo Horizonte (-2.3%), São Paulo (-2.5%), Curitiba (-2.8%) and Porto Alegre (-4.1%).Our findings showed differences in the incidence and mortality rates of MM in cAYA in Brazil, geographically. Infants-AML have the highest incidence within the cAYA population (17.42 per million). There was a substantial decrease in mortality rate observed, which was interpreted as an improvement in MM recognition and therapeutic approach.