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Epidemiological, pathological and immunohistochemical aspects of 125 cases of feline lymphoma in Southern Brazil

2019; Wiley; Volume: 18; Issue: 2 Linguagem: Inglês

10.1111/vco.12535

1476-5829

Ronaldo Viana Leite-Filho, Welden Panziera, Marcele Bettim Bandinelli, Luan Cleber Henker, Kalinka da Conceição Monteiro, Luís Gustavo Corbellini, David Driemeier, Luciana Sonne, Saulo Petinatti Pavarini,

Virus-based gene therapy research

Abstract A retrospective study compiling cases of feline lymphoma diagnosed during 12 years (2004‐2016) in Southern Brazil was performed. A total of 125 cases of lymphoma diagnosed in cats were reviewed, and information including age, breed, sex and tumour topography were collected. FeLV and FIV immunohistochemical tests were performed, as well as immunophenotyping of lymphomas. The alimentary form represented the most common presentation (42/125), followed by mediastinal lymphoma (35/125). Out of 125 cases, 79 presented positive retroviral immunostaining in tumour tissue (52 FeLV alone, 14 FIV alone and 13 presented FIV and FeLV co‐infections), 66/125 of the cases were of T‐cell origin and 59/125 of the cases were of B‐cell origin. The median age of cats with T‐cell lymphoma was 120 months (10‐240 months), and 60 months (6‐204 months) for cats with B‐cell lymphoma. The most frequent alimentary tumour presentation was the enteropathy‐associated T‐cell lymphoma (type 1), and the major type of mediastinal tumour observed was diffuse large B‐cell lymphoma. Considering only mediastinal and alimentary lymphomas (n = 77), the prevalence of mediastinal lymphoma in FeLV‐positive cats was 2.21 times higher than the prevalence of this type of tumour in FeLV‐negative cats ( P = .036). Mediastinal lymphoma was more frequently observed in younger cats, and the prevalence of mediastinal tumours in these animals was 3.06 times higher than the prevalence of this tumour form in old cats ( P = .0125). The present study indicates that retroviral infections still play an important role in the development of feline lymphomas in southern Brazil.