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Phytochemical analysis and evaluation of the antioxidant and antiproliferative effects of Tucumã oil nanocapsules in breast adenocarcinoma cells (MCF-7)

2019; Taylor & Francis; Volume: 35; Issue: 12 Linguagem: Inglês

10.1080/14786419.2019.1648460

1478-6427

Kátia Nascimento, Priscila Marquezan Copetti, Andrêssa S. Fernandes, Bruna Klein, Aline de Oliveira Fogaça, Leila Queiroz Zepka, Róger Wagner, Aline Ferreira Ourique, Michele Rorato Sagrillo, José Édson Paz da Silva,

Plant biochemistry and biosynthesis

In this work was to develop an inedited nanocapsule with tucumã oil (Astrocaryum vulgare). The oil presents of phytosterols (squalene and β-sitosterol), all-trans-beta-carotene, acids oleic and palmitic. Antioxidant activity showed a good performance in DPPH and ABTS assays. The nanocapsules were prepared and demonstrated in their characterization particle size (206 ± 0.69 nm). The cytogenotoxicity evaluation was performed using the MTT, dichlorofluorescein, nitric oxide and dsDNA PicoGreen® assays. Antitumor efficacy assays in MCF-7 cells demonstrated that free oil and tucumã nanocapsules had IC50 of 130 and 50 μg/mL, respectively. Thus, previous studies of toxicity are relevant, as they generate future subsidies, aiming at the potential application of nanostructures and in addition, the promising effect of NCs of tucumã oil on the antiproliferative effect in breast adenocarcinoma cells was evidenced.