Portal de Periódicos da CAPES

The role of immune regulatory molecules in multiple sclerosis

2019; Elsevier BV; Volume: 337; Linguagem: Inglês

10.1016/j.jneuroim.2019.577061

1872-8421

Boshra Afshar, Zahra Khalifehzadeh-Esfahani, Narges Seyfizadeh, Gholamreza Rezaei Danbaran, Maryam Hemmatzadeh, Hamed Mohammadi,

Immunotherapy and Immune Responses

Multiple sclerosis (MS) is the most common demyelinating disease which mainly impacts the integrity of central nervous system (CNS). MS etiology is not clearly known but genetic, environmental factors and immune system are the most frequently explored risk factors. Adaptive immune responses have a critical role in MS pathogenesis in which auto-reactive T-cells and autoantibodies are main orchestrators. Immune responses are modulated by inhibitory molecules which regulates adaptive system activation and hemostasis interface. These molecules suppress immune responses through inhibition of cytokine secretion and T cell proliferation and subsequently reducing the inflammation and respective damage. Therefore the critical role of inhibitory molecules in regulating the healthy and safe immune responses make them very attractive target for immunotherapy. In this review paper, the role of inhibitory molecules expressed on the various immune cell types in MS pathogenesis and experimental autoimmune encephalomyelitis (EAE) animal model will be summarized.