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Autophagy in intracellular bacterial infection

2019; Elsevier BV; Volume: 101; Linguagem: Inglês

10.1016/j.semcdb.2019.07.014

1096-3634

Wei Hu, Hung Chan, Lan Lu, K. T. Wong, Sunny H. Wong, Ming X Li, Zhan Xiao, Chi H. Cho, Tony Gin, Matthew T.V. Chan, William Ka Kei Wu, Lin Zhang,

Vibrio bacteria research studies

Autophagy is a conserved intracellular degradation process enclosing the bulk of cytosolic components for lysosomal degradation to maintain cellular homeostasis. Accumulating evidences showed that a specialized form of autophagy, known as xenophagy, could serve as an innate immune response to defend against pathogens invading inside the host cells. Correspondingly, infectious pathogens have developed a variety of strategies to disarm xenophagy, leading to a prolonged and persistent intracellular colonization. In this review, we first summarize the current knowledge about the general mechanisms of intracellular bacterial infections and xenophagy. We then focus on the ongoing battle between these two processes.