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Flexible Polycaprolactone and Polycaprolactone/Graphene Scaffolds for Tissue Engineering

2019; Multidisciplinary Digital Publishing Institute; Volume: 12; Issue: 18 Linguagem: Inglês

10.3390/ma12182991

1996-1944

Stanislav A. Evlashin, Pavel V. Dyakonov, Mikhail Tarkhov, S. A. Dagesyan, Sergei A. Rodionov, Anastasia Shpichka, M. O. Kostenko, Stepan Konev, Ivan Sergeichev, Peter Timashev, Iskander Akhatov,

Orthopaedic implants and arthroplasty

Developing bone scaffolds can greatly improve the patient's quality of life by accelerating the rehabilitation process. In this paper, we studied the process of composite polycaprolactone supercritical foaming for tissue engineering. The influence of graphene oxide and reduced graphene oxide on the foaming parameters was studied. The structural and mechanical properties were studied. The scaffolds demonstrated mechanical flexibility and endurance. The co-culturing and live/dead tests demonstrated that the obtained scaffolds are biocompatible. Different composite scaffolds induced various surface cell behaviors. The experimental data demonstrate that composite foams are promising candidates for in vivo medical trials.