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Cardiac Inflammatory Myofibroblastic Tumor

2019; Lippincott Williams & Wilkins; Volume: 12; Issue: 9 Linguagem: Inglês

10.1161/circimaging.119.009443

1942-0080

Tommaso D’Angelo, Silvio Mazziotti, Maria Cristina Inserra, Francesco De Luca, Salvatore Agati, Emilia Magliolo, Faraz Pathan, Alfredo Blandino, Placido Romeo,

Neuroendocrine Tumor Research Advances

HomeCirculation: Cardiovascular ImagingVol. 12, No. 9Cardiac Inflammatory Myofibroblastic Tumor Free AccessCase ReportPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissionsDownload Articles + Supplements ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toSupplementary MaterialsFree AccessCase ReportPDF/EPUBCardiac Inflammatory Myofibroblastic TumorA Multiparametric Imaging Approach Tommaso D'Angelo, MD, Silvio Mazziotti, MD, Maria Cristina Inserra, MD, Francesco De Luca, MD, Salvatore Agati, MD, Emilia Magliolo, MD, Faraz Pathan, MD, Alfredo Blandino, MD and Placido Romeo, MD Tommaso D'AngeloTommaso D'Angelo Tommaso D'Angelo, MD, "G. Martino" University Hospital Messina, Section of Radiology, Department of Biomedical Sciences and Morphological and Functional Imaging, Via Consolare Valeria 1, 98100 Messina, Italy. Email E-mail Address: [email protected] Section of Radiology, Department of Biomedical Sciences and Morphological and Functional Imaging (T.D., S.M., A.B.), "G. Martino" University Hospital Messina, Italy. , Silvio MazziottiSilvio Mazziotti Section of Radiology, Department of Biomedical Sciences and Morphological and Functional Imaging (T.D., S.M., A.B.), "G. Martino" University Hospital Messina, Italy. , Maria Cristina InserraMaria Cristina Inserra Department of Radiology (M.C.I., P.R.), "S. Vincenzo" Hospital Taormina, Messina, Italy. , Francesco De LucaFrancesco De Luca Section of Pediatric Cardiology, Department of Pediatric, Gynecologic, Microbiologic and Biomedical Sciences (F.D.L.), "G. Martino" University Hospital Messina, Italy. , Salvatore AgatiSalvatore Agati Mediterranean Pediatric Cardiology Center, "Bambino Gesù" Children's Hospital, Taormina, Messina, Italy (S.A.). , Emilia MaglioloEmilia Magliolo Department of Pathology (E.M.), "S. Vincenzo" Hospital Taormina, Messina, Italy. , Faraz PathanFaraz Pathan Department of Cardiology, Nepean Hospital, Sydney, New South Wales, Australia (F.P.). "C. Perkins" Centre, Nepean Clinical School—Sydney University, New South Wales, Australia (F.P.). , Alfredo BlandinoAlfredo Blandino Section of Radiology, Department of Biomedical Sciences and Morphological and Functional Imaging (T.D., S.M., A.B.), "G. Martino" University Hospital Messina, Italy. and Placido RomeoPlacido Romeo Department of Radiology (M.C.I., P.R.), "S. Vincenzo" Hospital Taormina, Messina, Italy. Originally published10 Sep 2019https://doi.org/10.1161/CIRCIMAGING.119.009443Circulation: Cardiovascular Imaging. 2019;12:e009443A 9-year-old boy with previous history of microhematuria and intermittent fever was admitted to hospital for routine screening. At presentation, he complained about recurrent shortness of breath and lethargy. His past medical history was unremarkable for cardiac symptoms. Laboratory data revealed normal white blood cells count (6700/μL), erythrocyte sedimentation rate, and C-reactive protein. The results of blood and urine cultures were negative.Physical examination and ECG did not reveal abnormalities. Transthoracic echocardiography showed a nonhomogeneous polypoid mass. It was arising from right ventricular outflow tract, projecting to pulmonary valve, and prolapsing to pulmonary artery during systole (Figure [A], Movie I in the Data Supplement).Download figureDownload PowerPointFigure. Cardiac inflammatory myofibroblastic tumor (IMT). Three chamber view in transthoracic echocardiography, (A) showing a polypoid mass (*) in right ventricular outflow tract. Cardiac magnetic resonance confirms the presence of a pedunculated tumor (arrow) prolapsing to main pulmonary trunk in end-systole (B). The mass is hyperintense in T2/T1-weighted cine-images (B), heterogeneously isointense in T1-weighted (C), and it does not show early or late gadolinium enhancement (D and E). Macroscopic (F and G) and histopathologic (H) appearance of cardiac IMT. Ao indicates aorta; LV, left ventricle; and RV, right ventricle.Cardiac magnetic resonance confirmed the presence of a mobile and pedunculated tumor with maximum size of 38×12 mm. It was hyperintense in T2/T1-weighted cine-images (Figure [B], Movie II in the Data Supplement), hyperintense in T2-weighted sequences, heterogeneously isointense in T1-weighted (Figure [C]), and without significant restriction of water diffusivity on diffusion-weighted imaging (b300).It did not show early enhancement at first-pass perfusion (Figure [D], Movie III in the Data Supplement), nor late gadolinium enhancement (Figure [E]). Ventricles were normal in size and function, with no evidence of myocardial late gadolinium enhancement. The provisional diagnosis of cardiac inflammatory myofibroblastic tumor (IMT) was made, which necessitated cardiac surgery. The child underwent tumor excision by means of median sternotomy and extracorporeal circulation. It revealed a mobile yellowish-white polypoid mass with a small pedicle attached to endocardium without signs of myocardial infiltration. The lesion was grossly firm, stringy, and partially beaded (Figure [F and G]).Histopathologic examination revealed a mesenchymal tumor composed of scattered spindle myofibroblasts, infiltration of lymphocytes, and plasma cells and sparse fibrin deposits on tumor surface (Figure [H]). Cells were positive for vimentin and smooth muscle actin and negative for CD34, myoD1, pancytokeratin, and anaplastic lymphoma kinase-1. The histopathology was consistent with IMT.After surgery, the patient recovered successfully with no evidence of tumor recurrence at 2-month follow-up echocardiography.With <60 cases reported in scientific literature, cardiac IMTs represent a very rare entity, which usually present as endocardial-based cavitary masses.1 The majority of cardiac IMTs have occurred in children and young adults, with a predominance for the right-side of the heart.The differential diagnosis includes myxoma, fibroelastoma, and low-grade sarcoma. MR imaging characteristics of cardiac IMT are not well described due to its rarity and depend on their cellular and myxoid composition.2 Cardiac magnetic resonance may substantially support the diagnosis, allowing for tissue characterization by evaluating the intrinsic (T1- T2- and diffusion-weighted imaging) and extrinsic tumor parameters (first-pass perfusion and late gadolinium enhancement imaging). In our case, heterogenous T2-hyperintensity and T1-isointensity of the cardiac mass were inconsistent with the diagnosis of thrombus. In addition, the absence of early or late gadolinium enhancement made the hypothesis of myxoma or low-grade sarcoma unlikely.Histopathology is essential for the diagnosis of IMT and spindled myofibroblastic proliferation with chronic inflammatory infiltrate represent the pathognomonic histological pattern.Etiopathogenesis of cardiac IMT is still uncertain, and despite some open controversies on its biologic nature, it is currently considered a benign low-grade neoplasm. However, because of its location within the heart, IMT may potentially be fatal due to high risk of embolic complications.3 Clinical symptoms and laboratory findings are aspecific, and the treatment should include surgery, despite a little potential for recurrences has been reported.DisclosuresNone.FootnotesThe Data Supplement is available at https://www.ahajournals.org/doi/suppl/10.1161/CIRCIMAGING.119.009443.Tommaso D'Angelo, MD, "G. Martino" University Hospital Messina, Section of Radiology, Department of Biomedical Sciences and Morphological and Functional Imaging, Via Consolare Valeria 1, 98100 Messina, Italy. Email [email protected]comReferences1. Eilers AL, Nazarullah AN, Shipper ES, Jagirdar JS, Calhoon JH, Husain SA. Cardiac inflammatory myofibroblastic tumor: a comprehensive review of the literature.World J Pediatr Congenit Heart Surg. 2014; 5:556–564. doi: 10.1177/2150135114546203CrossrefMedlineGoogle Scholar2. Tao TY, Yahyavi-Firouz-Abadi N, Singh GK, Bhalla S. Pediatric cardiac tumors: clinical and imaging features.Radiographics. 2014; 34:1031–1046. doi: 10.1148/rg.344135163CrossrefMedlineGoogle Scholar3. Burke A, Li L, Kling E, Kutys R, Virmani R, Miettinen M. Cardiac inflammatory myofibroblastic tumor: a "benign" neoplasm that may result in syncope, myocardial infarction, and sudden death.Am J Surg Pathol. 2007; 31:1115–1122. doi: 10.1097/PAS.0b013e31802d68ffCrossrefMedlineGoogle Scholar Previous Back to top Next FiguresReferencesRelatedDetailsCited By Gatti M, D'Angelo T, Muscogiuri G, Dell'aversana S, Andreis A, Carisio A, Darvizeh F, Tore D, Pontone G and Faletti R (2021) Cardiovascular magnetic resonance of cardiac tumors and masses, World Journal of Cardiology, 10.4330/wjc.v13.i11.628, 13:11, (628-649), Online publication date: 26-Nov-2021. Morales-Cardenas A, Semionov A and Kosiuk J (2020) Multiple pulmonary myofibromas mimicking metastatic disease in an adult patient, Radiology Case Reports, 10.1016/j.radcr.2020.09.044, 15:12, (2519-2521), Online publication date: 1-Dec-2020. Zhou X, Song L, Cheng Y, He C, He J and Han X (2022) Unusual case of a right atrial inflammatory myofibroblastic tumor presenting with an episodic cyanosis in an infant, Journal of Cardiac Surgery, 10.1111/jocs.16698 September 2019Vol 12, Issue 9 Advertisement Article InformationMetrics © 2019 American Heart Association, Inc.https://doi.org/10.1161/CIRCIMAGING.119.009443PMID: 31500449 Originally publishedSeptember 10, 2019 Keywordscardiac inflammatory myofibroblastic tumormyofibroblastscardiac massheart neoplasmsmagnetic resonance imagingdiagnosis, differentialcardiac pseudotumorPDF download Advertisement SubjectsImagingMagnetic Resonance Imaging (MRI)