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BIBTEX RIS

4-Hydroxy-pyran-2-one and 3-hydroxy-N-methyl-2-oxindole derivatives of Salinispora arenicola from Brazilian marine sediments

2019; Elsevier BV; Volume: 138; Linguagem: Inglês

10.1016/j.fitote.2019.104357

1873-6971

Alison B. da Silva, Francisco das Chagas Lima Pinto, Edilberto R. Silveira, Letícia V. Costa‐Lotufo, W. Saraiva Costa, Alejandro Pedro Ayala, Kirley Marques Canuto, Ayslan B. Barros, Ana Jérsia Araújo, José Delano Barreto Marinho Filho, Otília Deusdênia Loiola Pessoa,

Bioactive Compounds and Antitumor Agents

Three new 3-hydroxy-N-methyl-2-oxindole (1 and 2) and 4-hydroxy-pyran-2-one (3) derivatives, along with the known 3-hydroxy-N-methyl-2-oxindole (4) and 6-methoxy-N-methylisatin (5) were isolated from a marine Salinispora arenicola strain from sediments of the St. Peter and St. Paul Archipelago, Brazil. The structures of the new compounds were elucidated by a combination of spectroscopic (1D and 2D NMR and HR-ESIMS) data, including single-crystal X-ray diffraction analysis for 2 and 3. Compounds 1 to 5 were assayed for their antimicrobial properties, but only 4 and 5 were active against Enterococcus faecalis with MIC value of 15.6 μg/mL.