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Graviola Fruit Bar Added Acerola By-Product Extract Protects Against Inflammation and Nociception in Adult Zebrafish ( Danio rerio )

2019; Mary Ann Liebert, Inc.; Volume: 23; Issue: 2 Linguagem: Inglês

10.1089/jmf.2019.0078

1557-7600

Larissa Morais Ribeiro da Silva, Jorgiane da Silva Severino Lima, Francisco Ernani Alves Magalhães, Adriana Rolim Campos, José Ismael Feitosa de Araújo, Francisco Lucas Alves Batista, Sandra Maria Barbosa de Araújo, Paulo Henrique Machado de Sousa, Glauber Cruz Lima, Dayse Karine Rodrigues Holanda, Rhaul Cândido Rolim, Raimundo Wilane de Figueiredo, Evânia Altina Teixeira de Figueiredo, Antoniella Souza Gomes Duarte, Nágila Maria Pontes Silva Ricardo,

Marine Sponges and Natural Products

Studies involving foods associated with pain reversal and anti-inflammatory effects using zebrafish are rarely reported in the literature. This study aimed to evaluate the effect of graviola (Annona muricata L.) fruit bar (GFB) and GFB added with acerola (Malpighia glabra L) seed extract (ASE) on acute nociception and abdominal inflammation in adult zebrafish (Danio rerio). Acute nociception was induced by formalin, capsaicin, cinnamaldehyde, acidic saline, glutamate (cutaneous models), and hypertonic saline (corneal model), and inflammation was induced by carrageenan. Both GFB and ASE exhibited antinociceptive effect modulated by the nitrergic system, guanylate cyclase, and transient receptor potential ankyrin 1 and acid-sensing ion channels. The antinociceptive effect of GFB also appears to be modulated by the opioid system and glutamatergic receptors (N-methyl-D-aspartate receptor). Only ASE presented corneal antinociceptive effect. Both samples showed anti-inflammatory effect, being more significant the effect of GFB. The addition of acerola by-product extract in GFB results in a product with greater biological potential.