Association of multivitamin and alcohol intake with folate receptor alpha (FRα) expression in a case-control study of ovarian cancer
2005; American Association for Cancer Research; Volume: 65; Linguagem: Inglês
ISSN
1538-7445
AutoresLinda E. Kelemen, Thomas A. Sellers, Gary L. Keeney, Wilma L. Lingle, Lynn C. Hartmann,
Tópico(s)Folate and B Vitamins Research
Resumo5819 Background FRα overexpression in epithelial ovarian cancer (EOC) may confer a tumor growth advantage. We examined the relation between multivitamin use, a proxy for folic acid intake, with FRα expression in ovarian tumors and assessed whether the association was modified by alcohol intake, a folate agonist. Methods Cases (n=148) aged 20-80 years were seen at Mayo Clinic, MN between 1/00 and 8/04 with suspected EOC. Controls (n=148) without history of cancer and both ovaries intact were frequency matched to cases by age (5 years) and state. Lifestyle, medical and reproductive factors, regular multivitamin (≥ 4 pills per week) and weekly alcohol (≥ 5 vs
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