Portal de Periódicos da CAPES

Risk factors for Clostridioides difficile infection in hospitalized patients and associated mortality in Japan: a multi-centre prospective cohort study

2019; Elsevier BV; Volume: 104; Issue: 3 Linguagem: Inglês

10.1016/j.jhin.2019.09.012

1532-2939

Hitoshi Honda, Hiroo Kato, Margaret A. Olsen, Kimberly A. Reske, Mitsutoshi Senoh, Tadashi Fukuda, Yasuaki Tagashira, C Mahé, Erik R. Dubberke, Hiroko Horiuchi, Hiroshi Chiba, Daisuke Suzuki, Naoto Hosokawa, Hidetaka Kitazono, Yasuhiro Norisue, Kume Hisashi, N. Môri, H. Morikawa, Saeko Kashiwagura, Akiko Higuchi, Hiroo Kato, Masakazu Nakamura, Shin Ishiguro, Shinji Morita, Hidehiro Ishikawa, Tomomi Watanabe, K Kojima, Yokomaku Izumi, Tadashi Bando, Toimoto Kayoko, Kei Moriya, Ken Kasahara, Seigo Kitada, J Ogawa, H Saito, Harumi Tominaga, Yūji Shimizu, Fumi Masumoto, Kenjiro Tadera, Joji YOSHIDA, Takefumi Kikuchi, Ichiro Yoshikawa, Tomomi Watanabe, Masahisa Honda, Kumio Yokote, Tatsuya Toyokawa, Hirotaka Miyazato, Masakazu Nakama,

Helicobacter pylori-related gastroenterology studies

Background Although population characteristics and antimicrobial prescribing practices suggest that the hospitalized population in Japan is at high risk of Clostridioides difficile infection (CDI), the epidemiology of CDI in Japan is poorly understood. Aim This prospective cohort study aimed to investigate the epidemiology of CDI at 12 hospitals in Japan. Methods Patients with clinically significant diarrhoea (CSD) were enrolled. Stool specimens were tested for C. difficile by toxin A and/or B enzyme immunoassay (EIA) in the hospital laboratories, and a toxigenic culture and nucleic acid amplification tests were performed at a central laboratory. The risk factors of CDI and the impact of CDI on mortality were investigated. Findings In total, 566 patients with CSD were included in the analyses. A total of 152 patients received the diagnosis of CDI by Toxin A/B EIA, toxigenic culture, or nucleic acid amplification test. Factors associated with CDI included low albumin (adjusted odds ratio (aOR): 1.56; 95% confidence interval (CI): 1.03–2.34) and length of hospital stay before stool collection >18 days (aOR: 1.73; 95% CI: 1.09–2.75). CDI was associated with an increased mortality on univariate analysis (OR: 1.6, 95% CI: 1.0–2.6) but was not associated with an increased risk of mortality on multivariable analysis. Conclusion Risk factors for CDI in Japan were similar to those identified in the USA and Europe. However, CDI was not associated with an increased risk of mortality in this population of patients with CSD.