Artigo Acesso aberto Revisado por pares

Association of Birth Weight With Type 2 Diabetes and Glycemic Traits

2019; American Medical Association; Volume: 2; Issue: 9 Linguagem: Inglês

10.1001/jamanetworkopen.2019.10915

ISSN

2574-3805

Autores

Tao Huang, Tiange Wang, Yan Zheng, Christina Ellervik, Xiang Li, Meng Gao, Zhe Fang, Jin Fang Chai, Tarun veer S. Ahluwalia, Yujie Wang, Trudy Voortman, Raymond Noordam, Alexis C. Wood, Markus Scholz, Emily Sonestedt, Masato Akiyama, Rajkumar Dorajoo, Ang Zhou, Tuomas O. Kilpeläinen, Marcus E. Kleber, Sarah Crozier, Keith M. Godfrey, Rozenn N. Lemaître, Janine F. Felix, Yuan Shi, Preeti Gupta, Chiea Chuen Khor, Terho Lehtimäki, Carol A. Wang, Carla M. T. Tiesler, Elisabeth Thiering, Marie Standl, Peter Rzehak, Eirini Marouli, Meian He, Cécile Lecœur, Dolores Corella, Chao‐Qiang Lai, Luís A. Moreno, Niina Pitkänen, Colin Boreham, Tao Zhang, Seang‐Mei Saw, Paul M. Ridker, Mariaelisa Graff, Frank J.A. van Rooij, Andre G. Uitterlinden, Albert Hofman, Diana van Heemst, Frits R. Rosendaal, Renée de Mutsert, Ralph Burkhardt, Christina‐Alexandra Schulz, Ulrika Ericson, Yoichiro Kamatani, Jian‐Min Yuan, Chris Power, Torben Hansen, Thorkild I. A. Sørensen, Anne Tjønneland, Kim Overvad, Graciela Delgado, Cyrus Cooper, Luc Djoussé, Fernando Rivadeneira, Anthony James, Wanting Zhao, Jianjun Liu, Sang Lee, Olli T. Raitakari, Mika Kähönen, Jorma Viikari, Veit Grote, Jean‐Paul Langhendries, Berthold Koletzko, Joaquín Escribano, Elvira Verduci, George Dedoussis, Caizheng Yu, Yih‐Chung Tham, Blanche Lim, Sing Hui Lim, Philippe Froguel, Beverley Balkau, Nadia R. Fink, Rebecca Vinding, Astrid Sevelsted, Hans Bisgaard, Óscar Coltell, Jean Dallongeville, F. Gottrand, Katja Pahkala, Harri Niinikoski, Elina Hyppönen, Oluf Pedersen, Winfried März, Hazel Inskip, Vincent W. V. Jaddoe, Elaine Dennison, Tien Yin Wong, Charumathi Sabanayagam, E Shyong Tai, Karen L. Mohlke, David A. Mackey, Dariusz Gruszfeld, Panos Deloukas, Katherine L. Tucker, Frédéric Fumeron, Klaus Bønnelykke, Peter Rossing, Ramón Estruch, José M. Ordovás, Donna K. Arnett, Aline Meirhaeghe, Philippe Amouyel, Ching‐Yu Cheng, Xueling Sim, Yik Ying Teo, Rob M. van Dam, Woon‐Puay Koh, Marju Orho‐Melander, Markus Loeffler, Michiaki Kubo, Joachim Thiery, Dennis O. Mook‐Kanamori, Dariush Mozaffarian, Bruce M. Psaty, Oscar H. Franco, Tangchun Wu, Kari E. North, George Davey Smith, Jorge E. Chavarro, Daniel I. Chasman, Lu Qi,

Tópico(s)

Gestational Diabetes Research and Management

Resumo

Importance Observational studies have shown associations of birth weight with type 2 diabetes (T2D) and glycemic traits, but it remains unclear whether these associations represent causal associations. Objective To test the association of birth weight with T2D and glycemic traits using a mendelian randomization analysis. Design, Setting, and Participants This mendelian randomization study used a genetic risk score for birth weight that was constructed with 7 genome-wide significant single-nucleotide polymorphisms. The associations of this score with birth weight and T2D were tested in a mendelian randomization analysis using study-level data. The association of birth weight with T2D was tested using both study-level data (7 single-nucleotide polymorphisms were used as an instrumental variable) and summary-level data from the consortia (43 single-nucleotide polymorphisms were used as an instrumental variable). Data from 180 056 participants from 49 studies were included. Main Outcomes and Measures Type 2 diabetes and glycemic traits. Results This mendelian randomization analysis included 49 studies with 41 155 patients with T2D and 80 008 control participants from study-level data and 34 840 patients with T2D and 114 981 control participants from summary-level data. Study-level data showed that a 1-SD decrease in birth weight due to the genetic risk score was associated with higher risk of T2D among all participants (odds ratio [OR], 2.10; 95% CI, 1.69-2.61; P = 4.03 × 10 −5 ), among European participants (OR, 1.96; 95% CI, 1.42-2.71; P = .04), and among East Asian participants (OR, 1.39; 95% CI, 1.18-1.62; P = .04). Similar results were observed from summary-level analyses. In addition, each 1-SD lower birth weight was associated with 0.189 SD higher fasting glucose concentration (β = 0.189; SE = 0.060; P = .002), but not with fasting insulin, 2-hour glucose, or hemoglobin A 1c concentration. Conclusions and Relevance In this study, a genetic predisposition to lower birth weight was associated with increased risk of T2D and higher fasting glucose concentration, suggesting genetic effects on retarded fetal growth and increased diabetes risk that either are independent of each other or operate through alterations of integrated biological mechanisms.

Referência(s)