Artigo Produção Nacional Revisado por pares

Assessment of genotoxic effects on elderly populations exposed to high traffic areas: Results for supporting public health surveillance

2019; Elsevier BV; Volume: 179; Linguagem: Inglês

10.1016/j.envres.2019.108752

ISSN

1096-0953

Autores

Boscolli Barbosa Pereira, Vanessa Santana Vieira Santos, Érica Prado Domingues, Guilherme Gomes-Silva, Paolla Brandão da Cunha, Andrei Barbassa Oliveira, Lorrany Marins Mota, Edimar Olegário de Campos Júnior,

Tópico(s)

Noise Effects and Management

Resumo

In urban areas with intense vehicular traffic, particulate matter in suspension, especially the fraction of particles with ultra-fine diameter, has been regarded as the main problem of chronic diseases in susceptible populations, such as the elderly. This study aimed to determine the genotoxic effects of exposure to air pollution evaluating the association between the frequencies of micronuclei (MN) and binucleated (BN) cells in exfoliated oral mucosa cells of elderly population and exposure conditions, considering the influence of traffic and concentration of PM in different aerodynamic diameters. Traffic of passenger vehicles, heavy duty trucks and environmental concentrations of Particulate Matter were measured twice a day during 28 days before biological sampling of oral mucosa from 154 participants living in areas of distinct levels of urban traffic. Data from this study showed that the group of participants living near road traffic exhibited higher MN cell frequency, when compared to the other groups of subjects. In addition, a canonical correlation analysis between environmental and genotoxicity variables analysis revealed that high concentrations of the particulate matter were correlated with intense traffic and the genotoxicity in exfoliated oral cells.

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