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BIBTEX RIS

Peptide nucleic acid (PNA) and its applications in chemical biology, diagnostics, and therapeutics

2019; Elsevier BV; Volume: 52; Linguagem: Inglês

10.1016/j.cbpa.2019.06.006

ISSN

1879-0402

Autores

Jacques Saarbach, Pramod M. Sabale, Nicolas Winssinger,

Tópico(s)

RNA Interference and Gene Delivery

Resumo

Peptide nucleic acid (PNA) stands as one of the most successful artificial oligonucleotide mimetics. Salient features include the stability of hybridization complexes (either as duplexes or triplexes), metabolic stability, and ease of chemical modifications. These features have enabled important applications such as antisense agents, gene editing, nucleic acid sensing and as a platform to program the assembly of PNA-tagged molecules. Here, we review recent advances in these areas.

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