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Anti-Ulcer Effect of Aqueous Extract of Gynura cusimbua (D.Don) S.Moore on Swimming Stress Ulcer Model in Albino Rats

2019; Volume: 8; Issue: 33 Linguagem: Inglês

10.14260/jemds/2019/567

2278-4802

Bikram Tewari, Mayanglambam Medhabati,

Botanical Research and Chemistry

BACKGROUNDGynura cusimbua (D.Don) S.Moore.(Family: Compositae) which is commonly known as purple passion and is locally known as "terapaibi" is a traditionally and routinely used home remedy among the indigenous population of the state of Manipur, India.It has been used in various ailments and diseases like-control of bleeding from wounds and cuts, expediting wound healing, relief of common headache, faster healing, prevention of gastric ulcer and also for decreasing inflammation. METHODSThe present study was carried out to evaluate the anti-ulcer and gastro-protective property of Gynura cusimbua against the formation of gastric/peptic ulcer from exposure to stress by using a suitable experimental animal model that included subjecting the experimental animals to prolonged swimming in cold water as a stress factor to induce gastric ulcer.The division of animals (albino rats) was made into 5 groups that included 6 animals each, namely-Group I (Control-2% gum acacia in distilled water), Group II (Standard-Omeprazole 2 mg/Kg bodyweight), Group III (Test drug-500 mg/Kg body weight), Group IV (Test Drug-1000 mg/Kg bodyweight) and Group V (Test Drug-2000 mg/Kg body weight).The experimental animals in the different groups were administered the specified drugs orally using a gavage tube.The administration of drugs was done 30 minutes before they were subjected to a 3hour stress activity of swimming in cold water and the anti-ulcer activity was evaluated thereafter using ulcer index as the evaluating parameter. RESULTSThe test drug, aqueous extract of Gynura cusimbua, showed significant (p<0.05)reduction in ulcer index at doses of 2000 mg/Kg.body weight when compared to control.The test drug showed a dose dependant decrease in the formation/development of stress ulcer from the experiment, when compared to the control animal, justifying its age long persistent and continued use in the traditional medicine/healing practices for the treatment of gastric ulcer. CONCLUSIONSThis study adds data to the anti-inflammatory activity and an earlier study on the anti -ulcer effect of Gynura cusimbua in aspirin plus pylorus ligation model for gastric ulcers and further strengthens the safety of the plant extract for its traditional use in the treatment of peptic ulcer as well as research into the extraction, refinement and development of a novel chemical entity with anti-ulcer property.