Voltar
Artigo Acesso aberto Produção Nacional
BIBTEX RIS

Association between cognitive performance and SYT1-rs2251214 among women with cocaine use disorder

2019; Springer Science+Business Media; Volume: 126; Issue: 12 Linguagem: Inglês

10.1007/s00702-019-02086-w

ISSN

1435-1463

Autores

Thiago Wendt Viola, Jaqueline Bohrer Schuch, Diego Luiz Rovaris, Rafael Genovese, Lucca Pizzato Tondo, Breno Sanvicente‐Vieira, Aline Zaparte, Renata B. Cupertino, Bruna Santos da Silva, Claiton H.D. Bau, Rodrigo Grassi‐Oliveira,

Tópico(s)

Genetics and Neurodevelopmental Disorders

Resumo

The SNP rs2251214 of the SYT1 gene was recently associated with externalizing phenotypes, including ADHD and cocaine use disorder (CUD). Here, we investigated whether SYT1-rs2251214 could also be implicated with cognitive performance variations among women with CUD. Results showed that G homozygous (n = 146) have lower cognitive performance in the Stroop, Trail Making and Matrix Reasoning tests compared with A-allele carriers (n = 64), suggesting that rs2251214 may influence the severity of cognitive impairments in CUD.

Referência(s)