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Symptom-based stratification of patients with primary Sjögren's syndrome: multi-dimensional characterisation of international observational cohorts and reanalyses of randomised clinical trials

2019; Elsevier BV; Volume: 1; Issue: 2 Linguagem: Inglês

10.1016/s2665-9913(19)30042-6

2665-9913

Jessica Tarn, Nadia Howard-Tripp, Dennis Lendrem, Xavier Mariette, Alain Saraux, Valérie Devauchelle‐Pensec, Raphaèle Séror, Andrew Skelton, Katherine James, Peter McMeekin, Shereen Al-Ali, Katie L. Hackett, Clare Lendrem, Ben Hargreaves, John Casement, Sheryl Mitchell, Simon J Bowman, Elizabeth Price, Colin Pease, Paul Emery, Peter Lanyon, John Hunter, Monica Gupta, Stefano Bombardieri, Nurhan Sutcliffe, Costantino Pitzalis, John McLaren, Annie Cooper, Marian Regan, Ian Giles, David Isenberg, V. Saravanan, David Coady, Bhaskar Dasgupta, Neil McHugh, Steven Young‐Min, Robert J. Moots, Nagui Gendi, Mohammed Akil, Bridget Griffiths, Svein Joar Auglænd Johnsen, Katrine Brække Norheim, Roald Omdal, Deborah Stocken, Colin Everett, Catherine Fernandez, John D. Isaacs, Jacques‐Eric Gottenberg, Wan‐Fai Ng, Valérie Devauchelle‐Pensec, Philippe Dieudé, Jean Jacques Dubost, Anne-Laure Fauchais, Vincent Goëb, É. Hachulla, C. Larroche, Véronique Le Guern, Jacques Morel, Aleth Perdriger, Xavier Puéchal, S. Rist, Damien Sen, Jean Sibilia, Olivier Vittecoq, Joëlle Bénessiano, Sarah Tubiana, Karine Inamo, Stanie Gaëte, Djilali Batouche, Domitille Molinari, Mickael Randrianandrasana, Isabelle Pane, Adeline Abbé, Gabriel Baron, Philippe Ravaud, Jacques-Eric Gottenberg, Philippe Ravaud, Xavier Puéchal, Véronique Le Guern, Jean Sibilia, C. Larroche, Alain Saraux, Valérie Devauchelle-Pensec, Jacques Morel, Gilles Hayem, P.Y. Hatron, Aleth Perdriger, Damien Sene, Charles Zarnitsky, Djilali Batouche, Valérie Furlan, Joëlle Bénessiano, Élodie Perrodeau, Raphaèle Séror, Xavier Mariette, Samuel M. Brown, N. Navarro, Saaeha Rauz, Paul Emery, Sue Pavitt, Joanne Gray, Claire Hulme, F Hall, R Busch, P. Smith, L Dawson, Stefano Bombardieri, Wan‐Fai Ng, C Pease, Elizabeth Price, Nurhan Sutcliffe, Clodagh Woods, S Ruddock, Colin Everett, Catherine Reynolds, Elizabeth A. Skinner, A Poveda-Gallego, J. Rout, Iain MacLeod, Saaeha Rauz, Simon Bowman, Wan‐Fai Ng, Simon J Bowman, Bridget Griffiths, Frances Hall, Elalaine C Bacaba, Helen Frankland, Robert J. Moots, Kuntal Chadravarty, Shamin Lamabadusuriya, Stefano Bombardieri, Constantino Pitzalis, Nurhan Sutcliffe, Celia Breston, Nagui Gendi, Karen Culfear, Claire Riddell, John Hamburger, Andrea Richards, Saaeh Rauz, S Brailsford, Joanne Dasgin, Joanne Logan, D. Mulherin, Jacqueline Andrews, P. Emery, Alison McManus, Colin Pease, David Pickles, Alison Booth, Marian Regan, Jon King Kin, Amanda Holt, Theodoros Dimitroulas, Lucy Kadiki, Daljit Kaur, George Kitas, Abdul Haque Khan, Tracey Cosier, Panthakalam, Kell Mintrim, Mark Lloyd, Lisa Moore, Esther Gordon, Cathy Lawson, Monica Gupta, John Hunter, Lesley Stirton, G. Torres Ortiz, Elizabeth Price, Suzannah Pelger, Claire Gorman, Balinder Hans, Gavin Clunie, Suzanne Lane, Ginny Rose, Sue Cuckow, M. Batley, Ruby Einosas, Susan Knight, Deborah Symmons, Beverley Jones, Andrew Carr, Suzanne Edgar, Francisco Figuereido, H. Foggo, Dennis Lendrem, Iain MacLeod, Sheryl Mitchell, Christine Downie, Jessica Tarn, James Locke, Shereen Al-Ali, Sarah Legg, Kamran Mirza, Ben Hargreaves, Laura Hetherington, Adrian Jones, Peter Lanyon, Alice Muir, Paula White, Steven Young‐Min, Susan Pugmire, V. Saravanan, Annie Cooper, Marianne Watkins, Anne Field, Stephen B. Kaye, Devesh Mewar, Patricia Medcalf, Pamela Tomlinson, Debbie Whiteside, Neil McHugh, John D Pauling, Julie James, Andrea Dowden, Mohammed Akil, Jayne McDermott, Olivia Godia, David Coady, Elizabeth Kidd, Lynne Palmer, Charles Li, Sarah Bartrum, D Mead, Bhaskar Dasgupta, Victoria Katsande, Pamela O. Long, Erin Vermaak, J. Turner, Usha Chandra, Kirsten Mackay, Stefano Fedele, Ada Ferenkeh-Koroma, Ian Giles, David Isenberg, Helena MaConnell, Nyarko Ahwiren, Stephen Porter, Paul Allcoa, John McLaren,

Salivary Gland Tumors Diagnosis and Treatment

Heterogeneity is a major obstacle to developing effective treatments for patients with primary Sjögren's syndrome. We aimed to develop a robust method for stratification, exploiting heterogeneity in patient-reported symptoms, and to relate these differences to pathobiology and therapeutic response.