Produção Nacional
Revisado por pares
A rare case of bevacizumab-related osteonecrosis of the jaw associated with dental implants
2019; Springer Science+Business Media; Volume: 5; Issue: 1 Linguagem: Inglês
10.1186/s40729-019-0188-0
ISSN2198-4034
AutoresGustavo Maluf, Rogério Jardim Caldas, Eduardo Rodrigues Fregnani, Paulo Sérgio da Silva Santos,
Tópico(s)Sarcoidosis and Beryllium Toxicity Research
ResumoMedication-related osteonecrosis of the jaw (MRONJ) is characterized by the development of bone necrosis in the jaws of patients receiving antiresorptive and/or antiangiogenic medications. No scientific reports have been published yet on bevacizumab-related osteonecrosis of the jaw (BeRONJ) when associated with dental implant placement and adjuvant ozone therapy.A 54-year-old female patient with a history of metastatic breast cancer and bevacizumab use presented with a dental infection. Dental extraction followed immediately by dental implant placement was planned after suspension of the bevacizumab treatment. The patient presented with pain, drainage of purulent secretion, and bone exposure 5 weeks post-surgery. Complete healing was achieved at postoperative 7 months.The combination of adjuvant ozone therapy and surgical debridement was effective for the treatment of MRONJ; however, the risk of MRONJ may persist after the suspension of bevacizumab for 28 days.
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