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Blood eosinophils could be useful as a biomarker in chronic obstructive pulmonary disease exacerbations

2019; Wiley; Volume: 73; Issue: 12 Linguagem: Inglês

10.1111/ijcp.13423

1742-1241

Francisco Javier González‐Barcala, Maria‐Esther San‐Jose, Juan José Nieto‐Fontarigo, Uxío Calvo-Álvarez, José M. Carreira, María-Teresa García-Sanz, Xavier Muñoz, Maria-Purificacion Perez‐Lopez‐Corona, Maria-Jose Gómez‐Conde, Alejandro Casas‐Fernández, Luís Valdés, Lara Mateo‐Mosquera, Francisco J. Salgado,

Respiratory Support and Mechanisms

1 Introduction The aim of analysing the usefulness of the blood eosinophil count (BEC) as a prognostic marker in exacerbations of patients with Chronic Obstructive Pulmonary Disease (COPD), evaluating its relationship with hospital mortality, the length of stay and the early and late re-admissions. 2 Materials and Methods We have carried out a retrospective study including all patients who required hospital admission from 1 January 2008 to 31 December 2009, with a diagnosis on hospital discharge of COPD exacerbation. These patients were classified using three cut-off points of BEC: less than 200 vs ≥ 200/µL, less than 300 vs ≥ 300/µL and less than 400 vs ≥ 400/µL. 3 Results There were a total of 1626 hospital admissions during the study period with the diagnosis of exacerbation of COPD. In this study we have included 358 patients. The probability of any late re-admission increased with a BEC ≥ 300/µL (odds ratio: 1.684) and for those with a BEC ≥ 400/µL (odds ratio: 2.068). The BEC does not appear to be related to hospital mortality or the probability of early re-admission after an exacerbation of COPD. 4 Conclusions In our study an elevated BEC is associated with a higher incidence of late hospital readmissions in COPD exacerbations. What’s known In the last few years, the eosinophils have been recognised as an important mediator in patients with chronic obstructive pulmonary disease (COPD). The impact of blood eosinophil count on the prognosis of COPD exacerbations is still under debate. What’s new In our study, which includes a large sample size, an elevated blood eosinophil count is associated with a higher incidence of late hospital readmissions in COPD exacerbations.