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β-Caryophyllene promotes oxidative stress and apoptosis in KB cells through activation of mitochondrial-mediated pathway – An in-vitro and in-silico study

2019; Taylor & Francis; Volume: 128; Issue: 1 Linguagem: Inglês

10.1080/13813455.2019.1669057

1744-4160

Duraisamy Ramachandhiran, Chandrasekaran Sankaranarayanan, Raju Murali, Sukumar Babukumar, Veerasamy Vinothkumar,

Natural Compounds in Disease Treatment

Beta-caryophyllene (BCP), are natural bicyclic sesquiterpenes which are present in numerous plants worldwide. BCP has antioxidant, antimicrobial, and antifungal properties. Here, we studied its anticancer, anti-inflammatory, and cytotoxic effects. Cells treated with BCP, in a dose-dependent manner, exhibited morphological changes, showed lower cell growth, underwent apoptosis and lost the ability to metastasis through the suppression of NF-ҡ B via PI3K/AKT signalling pathway. These results elucidate that the inhibition of NF-ҡ B and PI3K/AKT is one of the most important mechanism by which BCP suppresses cancer cell proliferation and enhances apoptosis.