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Effect of B-site doping on Sr2PdO3 perovskite catalyst activity for non-enzymatic determination of glucose in biological fluids

2019; Elsevier BV; Volume: 852; Linguagem: Inglês

10.1016/j.jelechem.2019.113523

1873-2569

Nada F. Atta, Ahmed Galal, Ekram H. El‐Ads,

Electrochemical Analysis and Applications

For the first time, a sensitive, selective and durable non-enzymatic glucose electrode was introduced based on Au-doped strontium palladium nano-perovskite modified graphite sensor. The effect of the metal dopant type in B-site of Sr2PdO3 perovskite; (M: Ni2+, Cu2+, Au3+, and Pt2+) was evaluated. Sr2Pd0.7Au0.3O3 modified graphite sensor with molar concentration of dopant 0.3 showed the highest electro-catalytic activity for non-enzymatic glucose sensing. The high catalytic activity of Sr2Pd0.7Au0.3O3 is attributed to the inclusion of highly conductive Au3+ dopant, generation of extra oxygen vacancies, enhancement of electronic and ionic conductivity, and stabilization of the orthorhombic perovskite structure. The proposed non-enzymatic glucose sensor offered high performance in terms of amperometric measurements in real serum samples, wide concentration range; 0.2 μM–100 μM, high sensitivity; 1.44 × 104 μA mM−1 cm−2, low detection limit; 2.11 nM and anti-interference ability. Also, this sensor offered long term stability and good shelf time up to one month with repetitive usage.