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Transcriptional Regulation of Energy Metabolism in Cancer Cells

2019; Multidisciplinary Digital Publishing Institute; Volume: 8; Issue: 10 Linguagem: Inglês

10.3390/cells8101225

2073-4409

Sara Rodríguez‐Enríquez, Álvaro Marín‐Hernández, Juan Carlos Gallardo‐Pérez, Silvia Cecilia Pacheco-Velázquez, Javier Belmont-Díaz, Diana Xochiquetzal Robledo‐Cadena, Jorge Luis Vargas-Navarro, Norma Angélica Corona de la Peña, Emma Saavedra, Rafael Moreno‐Sánchez,

Metabolism, Diabetes, and Cancer

Cancer development, growth, and metastasis are highly regulated by several transcription regulators (TRs), namely transcription factors, oncogenes, tumor-suppressor genes, and protein kinases. Although TR roles in these events have been well characterized, their functions in regulating other important cancer cell processes, such as metabolism, have not been systematically examined. In this review, we describe, analyze, and strive to reconstruct the regulatory networks of several TRs acting in the energy metabolism pathways, glycolysis (and its main branching reactions), and oxidative phosphorylation of nonmetastatic and metastatic cancer cells. Moreover, we propose which possible gene targets might allow these TRs to facilitate the modulation of each energy metabolism pathway, depending on the tumor microenvironment.