Portal de Periódicos da CAPES

Substance P Level in Tears as a Potential Biomarker for Contact Lens Discomfort

2019; Taylor & Francis; Volume: 29; Issue: 1 Linguagem: Inglês

10.1080/09273948.2019.1668024

1744-5078

Alberto López‐de la Rosa, Carmen García‐Vázquez, Itziar Fernández, Cristina Arroyo-del Arroyo, Amalia Enríquez–de-Salamanca, María J. González‐García,

Corneal Surgery and Treatments

Purpose: To analyze the effects of contact lens (CL) wear, time of the day, and CL discomfort (CLD) on clinical signs, tear inflammatory mediators and substance P.Methods: Thirty symptomatic and 30 asymptomatic CL wearers attended two visits (morning and afternoon) on two days (non-CL and CL wearing days). Comfort, meniscus area, noninvasive breakup time (NIBUT), tear collection, hyperemia, lid parallel conjunctival folds, fluorescein staining, and sensitivity were performed. The tear levels of 23 inflammatory mediators and substance P were measured.Results: Comfort, meniscus area, NIBUT, and MMP-9 were lower while conjunctival staining and EGF higher (p ≤ 0.015) on the CL wearing day. Comfort, IL-8/CXCL8, and VEGF were lower while EGF, IP-10/CXCL10, and MCP-1/CCL2 higher (p ≤ 0.047) in the afternoon. Comfort was lower and substance P higher (p ≤ 0.006) in symptomatic wearers.Conclusion: Substance P may be implicated in CLD etiology; its role and potential application as a biomarker should be further studied.