Portal de Periódicos da CAPES

¿Sigue siendo la parafenilendiamina un alérgeno de contacto prevalente en España?

2019; Elsevier BV; Volume: 111; Issue: 1 Linguagem: Inglês

10.1016/j.ad.2019.04.003

1695-4734

J. Sánchez‐Pérez, M.Á. Descalzo, J.F. Silvestre, Virginia Fernández‐Redondo, J. García‐Gavín, Inmaculada Ruíz González, Pedro Mercader, José Carlos Armario Hita, I. García‐Doval, Ana M. Giménez‐Arnau,

Pesticide Exposure and Toxicity

To analyze trends in the prevalence of contact sensitization to p-phenylenediamine between 2004 and 2014, taking into consideration that the concentration of this product in cosmetics was regulated in 2009. To explore risk factors for contact allergy to p-phenylenediamine.Retrospective observational study of patients suspected of having contact dermatitis from allergy to p-phenylenediamine during the years between 2004 and 2015 in 8 tertiary level hospitals. The patients underwent patch testing (TRUE-test) with the standard series of the Spanish Research Group on Contact Dermatitis and Skin Allergies. This series included p-phenylenediamine 1%. We followed international recommendations for the statistical analysis of data related to contact allergies.Three hundred eighty-six out of 9341 patients (4.1%) had positive reactions to p-phenylenediamine. The prevalence tended to decrease in the early years (2004-2007) and then leveled off at around 4%. Risk factors for developing contact dermatitis from p-phenylenediamine were sex, age over 40 years, multiple sensitivities, and profession, notably workers in hair salons and those who handle rubber and plastics.The prevalence of p-phenylenediamine allergy remains high among patients with contact eczema. Risk factors for p-phenylenediamine contact allergy are consistent with previous reports.