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Room Temperature Synthesis and Characterization of Novel Bi(III) Complex with 2-Amino-3- Carbomethoxy-4,5,6,7-Tetrahydrobenzo[B]Thiophene as Potential Antimicrobial Agent

2020; Slovenian Chemical Society; Volume: 67; Issue: 1 Linguagem: Inglês

10.17344/acsi.2019.5365

1580-3155

Emmanuel Sopbué Fondjo, Désire André Siéwé, Jean‐de‐Dieu Tamokou, Steve Endeguele Ekom, Sorel Kamal Dimo Djeukoua, Giscard Doungmo, Mallory E. Walters, Appolinnaire Tsopmo, Peter F. W. Simon, Jules Roger Kuiaté,

Multicomponent Synthesis of Heterocycles

A novel bismuth(III) complex with 2-amino-3-carbomethoxy - 4,5,6,7-tetrahydrobenzo[ b ]thiophene (ACTT) as a ligand have been synthesized. The novel complex was characterized on the basis of its IR, NMR, elemental analysis and MS spectral data. It was found that the ligand behaves as a monodentate chelating agent and bonds to the metal ion through the nitrogen atom of the amino group to form the [Bi III (ACTT) 6 ]Cl 3 complex. The new complex compound displayed significant antimicrobial activity (MIC = 8–32 μg/mL) against Bacillus subtilis , Staphylococcus aureus, Escherichia coli , Pseudomonas aeruginosa , Shigella flexneri, Candida albicans , Candida tropicalis and Cryptococcus neoformans .