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Streptococcus pyogenes pbp2x Mutation Confers Reduced Susceptibility to β-Lactam Antibiotics

2019; Oxford University Press; Volume: 71; Issue: 1 Linguagem: Inglês

10.1093/cid/ciz1000

1537-6591

Kirsten Vannice, Jessica N. Ricaldi, Srinivas Nanduri, Ferric C. Fang, John B. Lynch, Chloe Bryson‐Cahn, Theodore Wright, Jeff Duchin, Meagan Kay, Sopio Chochua, Chris Van Beneden, Bernard Beall,

Infective Endocarditis Diagnosis and Management

Two near-identical clinical Streptococcus pyogenes isolates of emm subtype emm43.4 with a pbp2x missense mutation (T553K) were detected. Minimum inhibitory concentrations (MICs) for ampicillin and amoxicillin were 8-fold higher, and the MIC for cefotaxime was 3-fold higher than for near-isogenic control isolates, consistent with a first step in developing β-lactam resistance.