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Terpinen-4-ol Inhibits the Growth of Sporothrix schenckii Complex and Exhibits Synergism with Antifungal Agents

2019; Future Medicine; Volume: 14; Issue: 14 Linguagem: Inglês

10.2217/fmb-2019-0146

1746-0921

Raimunda SN Brilhante, Vandbergue Santos Pereira, Jonathas Sales de Oliveira, Anderson Messias Rodrigues, Zoilo Pires dè Camargo, Waldemiro Aquino Pereira-Neto, Nilberto Robson Falcão do Nascimento, Débora S.C.M. Castelo-Branco, Rossana de Aguiar Cordeiro, José Júlio Costa Sidrim, Marcos Fábio Gadelha Rocha,

Fungal Infections and Studies

Aim: This study investigated the effect of terpinen-4-ol against Sporothrix schenckii complex and its interactions with antifungals. Materials & methods: The antifungal activity of terpinen-4-ol was evaluated by broth microdilution. The potential effect on cellular ergosterol concentration was evaluated by spectrophotometry. The antibiofilm activity was evaluated by violet crystal staining and XTT reduction assay. The potential pharmacological interactions with antifungals were evaluated by the checkerboard assay. Results: terpinen-4-ol (T-OH) showed minimal inhibitory concentrations ranging from 4 to 32 mg/l decreasing cellular ergosterol content and presented a SMIC ranging from 64 to 1024 mg/l for Sporothrix spp. The combinations of T-OH with itraconazole or terbinafine were synergistic. Conclusion: T-OH has antifungal activity against Sporothrix spp. and acts synergistically with standard antifungals.