Portal de Periódicos da CAPES

Artigo Acesso aberto Produção Nacional Revisado por pares

BIBTEX RIS

Efficacy of Baccharis dracunculifolia in the treatment of diversion colitis in rats

2019; Thieme Medical Publishers (Germany); Volume: 40; Issue: 01 Linguagem: Inglês

10.1016/j.jcol.2019.09.001

2317-6423

Arthur Medeiros LIMA, Carlos Eduardo Costa Nascimento, Carlos Henrique Marques dos Santos, Doroty Mesquita Dourado, Gabriel Elias Cardoso Siqueira, Giovana Maria Rigo, Lauren Umpierre Bernardi, Paulo Otávio Souza Leonel, Rosemary Matias, Vitor Caldas FERREIRA, Vítor Cruz Rosa Pires de Souza,

Inflammatory Bowel Disease

Abstract Rationale Disuse colitis is frequent in our country and the most effective treatment is high cost and there is a need for effective and low cost therapy. Objective To evaluate the efficacy of Baccharis dracunculifolia (field rosemary) in the treatment of exclusion colitis in rats. Method Eighteen Wistar rats were anesthetized and submitted to colostomy; they were then distributed into two groups: Control Group, receiving intrarectal saline infusion (n = 8) and Group BD receiving intrarectal infusion ofBaccharis dracunculifolia extract (n = 10); after 21 days of treatment they were euthanized, the intestinal segment excluded from intestinal transit was resected and submitted to histopathological study, classifying the degree of inflammation and degree of vascular congestion from 0 to 3. Results Mean inflammation was 2.7 in Control Group versus 2.1 in BD Group (p = 0.049), while mean vascular congestion was 2.3 and 2, respectively, in Control and BD groups (p = 0.1642). Conclusion Intra-rectal infusion ofBaccharis dracunculifolia extract significantly minimized the inflammatory process in the exclusion colitis of rats submitted to colostomy, without altering the degree of vascular congestion.