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Risk factors for depression in adults: NR3C1 DNA methylation and lifestyle association

2019; Elsevier BV; Volume: 121; Linguagem: Inglês

10.1016/j.jpsychires.2019.10.011

1879-1379

Aline Ribeiro Borçoi, Suzanny Oliveira Mendes, Joaquim Gasparini dos Santos, Mayara Mota de Oliveira, Ivana Alece Arantes Moreno, Flávia Vitorino Freitas, Júlia Assis Pinheiro, Juliana Krüger Arpini, Ester Ribeiro Cunha, Anderson Barros Archanjo, Arícia Leone Evangelista Monteiro de Assis, Bruna Pereira Sorroche, Lídia Maria Rebolho Batista Arantes, Elizeu Borloti, Adriana Madeira Àlvares da Silva,

Intergenerational Family Dynamics and Caregiving

The aim of this study was to verify determinant factors for depression and analyze the relationship between possible changes in HPA axis and depression, in this case NR3C1 DNA methylation and serum cortisol levels. 349 adult volunteers were recruited to evaluate depression, socio-demographic, economic and lifestyle factors, serum cortisol levels and NR3C1 DNA methylation by pyrosequencing. Depression determinant factors were investigated using a Poisson regression model with robust variance (p < 0.05). Poisson regression with robust variance adjusted by gender, tobacco use, self-perceived stress, leisure activity, suicidal ideation, low cortisol levels and NR3C1 DNA methylation was performed and predicted risk factors for depression. Furthermore, depressive volunteers showed a significant increase in NR3C1 DNA methylation when compared to healthy volunteers. This findings provide a basis for understanding the role of HPA axis in depression, especially its regulation by NR3C1 DNA methylation. Furthermore, it emphasizes the stressful lifestyle risk factors (female, tobacco uso, self perceived stress, leisure activities absence and suicidal ideation) that can contribute to future research and the search for public health policies to improve quality of live, mental and general health.