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Biofilm production and distribution of pilus variants among Streptococcus agalactiae isolated from human and animal sources

2019; Taylor & Francis; Volume: 35; Issue: 8 Linguagem: Inglês

10.1080/08927014.2019.1678592

1029-2454

Danielle Cristina Santos Silva Alvim, Ana Flávia Martinho Ferreira, Matheus Amaral Leal, Laura Maria Andrade Oliveira, Ana Maria Nunes Botelho, Ana Caroline N. Botelho, Agnes Marie Sá Figueiredo, Sérgio Eduardo Longo Fracalanzza, Lúcia Martins Teixeira, Tatiana Castro Abreu Pinto,

Antimicrobial Resistance in Staphylococcus

Streptococcus agalactiae (group B Streptococcus, GBS) is a major pathogen in humans and animals. Pili and biofilm may be important virulence factors in this bacterial species. Here, biofilm production and the distribution of pilus variants among 134 GBS isolates from human and animal sources were evaluated. Biofilm production was significantly enhanced in 1% glucose-supplemented medium (p < 0.05). Using this medium, most GBS strains were strong biofilm producers. Biomass was mainly composed of proteins, followed by extracellular DNA, while polysaccharides represented a minor portion. All GBS strains presented at least one pilus variant. PI-2a was the most common among human GBS while PI-2b was the most common among animal isolates. Human GBS harboring PI-2b and animal GBS harboring PI-2a presented significantly reduced biofilm production (p = 0.0033). In conclusion, strong biofilm production seems to be a common characteristic in GBS, and association of the clinical source with the pilus variant may be crucial for this.