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Can [18F]F-FDG PET/CT be used to assess the pre-operative extent of peritoneal carcinomatosis in patients with colorectal cancer?

2019; Springer Nature; Volume: 45; Issue: 2 Linguagem: Inglês

10.1007/s00261-019-02268-w

2366-004X

Fortuné M.K. Elekonawo, Bas J. Starremans, Sander Thomas Laurens, Andreas J. A. Bremers, Johannes H.W. de Wilt, Linda Heijmen, Lioe‐Fee de Geus‐Oei,

Hernia repair and management

Abstract Purpose To evaluate whether PET/CT could be used to assess the extent of colorectal peritoneal metastases. Methods All patients who underwent a PET/CT scan before a CRS-HIPEC procedure between January 1, 2010 and December 31, 2013 were retrospectively included ( n = 35). Two nuclear medicine physicians (observer 1 and observer 2) separately reviewed the scans on intraperitoneal abnormalities. A simplified PCI was used to compare the extent of rPCI versus sPCI. Results Included patients had a median age of 60.6 years. Histology of primary tumors were 51.5% adenocarcinomas, 37.1% mucinous adenocarcinoma, and 11.4% SRCC. Median sPCI was 9.5 (5.0–11.8) and median rPCI was 5.0 (3.0–7.0) for observer 1 and 4.0 (3.0–6.0) for observer 2 ( p = 0.02 and p = 0.01, respectively). When compared to the surgical data, PET/CT showed a poor correlation for assessing the extent of PC for both adenocarcinoma (observer 1 rho – 0.17, p = 0.51 and observer 2 rho 0.13, p = 0.61) as well as mucinous carcinoma or SRCC (observer 1 rho 0.44, p = 0.08 and observer 2 rho 0.38, p = 0.14). Conclusion PET/CT underestimates the extent of PC during surgery in both mucinous and non-mucinous CRC and is not recommended for intraperitoneal tumor scoring.