Portal de Periódicos da CAPES

The Predictive Role of the Biomarker Kidney Molecule-1 (KIM-1) in Acute Kidney Injury (AKI) Cisplatin-Induced Nephrotoxicity

2019; Multidisciplinary Digital Publishing Institute; Volume: 20; Issue: 20 Linguagem: Inglês

10.3390/ijms20205238

1661-6596

Daniela Maria Tănase, Evelina Maria Gosav, Smaranda Radu, Claudia Florida Costea, Manuela Ciocoiu, Alexandru Cărăuleanu, C.M. Lǎcǎtusu, Minela Aida Mărănducă, Mariana Floria, Ciprian Rezuș,

Pharmacological Effects and Toxicity Studies

Acute kidney injury (AKI) following platinum-based chemotherapeutics is a frequently reported serious side-effect. However, there are no approved biomarkers that can properly identify proximal tubular injury while routine assessments such as serum creatinine lack sensitivity. Kidney-injury-molecule 1 (KIM-1) is showing promise in identifying cisplatin-induced renal injury both in vitro and in vivo studies. In this review, we focus on describing the mechanisms of renal tubular cells cisplatin-induced apoptosis, the associated inflammatory response and oxidative stress and the role of KIM-1 as a possible biomarker used to predict cisplatin associated AKI.