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Dormant pathogenic CD4+ T cells are prevalent in the peripheral repertoire of healthy mice

2019; Nature Portfolio; Volume: 10; Issue: 1 Linguagem: Inglês

10.1038/s41467-019-12820-3

2041-1723

Anna Cebula, Michal Kuczma, Edyta Szurek, Maciej Pietrzak, Natasha M. Savage, Wessam Elhefnawy, Grzegorz A. Rempała, Piotr Kraj, Leszek Ignatowicz,

Immunotherapy and Immune Responses

Thymic central tolerance eliminates most immature T cells with autoreactive T cell receptors (TCR) that recognize self MHC/peptide complexes. Regardless, an unknown number of autoreactive CD4