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Severe asthma phenotypes in patients controlled with omalizumab: A real-world study

2019; Elsevier BV; Volume: 159; Linguagem: Inglês

10.1016/j.rmed.2019.105804

1532-3064

Paloma Campo, José Gregorio Soto Campos, Marina Blanco–Aparicio, Ana Moreira Jorge, Héctor Manuel González Expósito, Santiago Quirce, Ignacio Dávila,

Allergic Rhinitis and Sensitization

BackgroundThe appropriate identification of asthma phenotypes of responders to omalizumab would optimize the selection of treatment.ObjectiveTo describe the most frequent clinical phenotypes in patients with severe asthma responding to omalizumab and their clinical and pulmonary function improvement.MethodsThis was an observational, retrospective, multicenter study. Adult patients with severe asthma, who achieved good control after the first year of treatment with omalizumab were included. Omalizumab was prescribed according to clinical routine practice. Responders were assigned to one pre-established phenotype based on the most predominant one before they had started treatment with omalizumab, all according to the physician's criteria. Data about asthma symptoms, number of non-severe asthma exacerbations, medication intake (inhaled and oral corticosteroids and rescue medication), lung function, high fractional exhaled nitric oxide (FeNO) and peripheral eosinophils counts were recorded.ResultsAmong the 345 patients included, the main phenotypes were severe asthma with frequent exacerbations (29.9%), early-onset allergic asthma (23.8%), severe steroid-dependent asthma (18.8%), and severe eosinophilic asthma (13.6%). Clinical and respiratory changes observed after first year of treatment with omalizumab included: reduction in asthma symptoms, reduction in the use and dose of corticosteroids and need for rescue therapy, improvement of pulmonary function, reduction in the number of episodes of non-severe asthma exacerbations regardless of the duration of severe disease since the diagnosis. Increased blood levels of peripheral eosinophils and high FeNO levels were found at baseline.ConclusionSeveral heterogeneous severe asthma phenotypes were observed as good responders to omalizumab.